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Set in noughties Britain, Mouth to Mouth deals with six young adults as they enter their twenties and realise that there is more to status than a Facebook update. Each year-in-the-life episode concentrates on one character's story as their lives intertwine and sometimes collide. Small events have big effects and molehills become mountains, as each of them scrabble to find their way and discover that be it comic, tragic and unpredictable, modern life can be tough.

Meeshell Reeves, singer with pop-duo Cats Eyes, wants nothing more than to be famous. When TV talent show Fame Search offers her an audition, her fantasy life comes tantalisingly into reach.

Reluctantly aided by her best friend Devine and her long-suffering boyfriend Tyler, the audition date looms and Meeshell prepares to leave her old life behind. But when she is offered a choice between stardom and friendship, can she make the right decision? And what price is she prepared to pay to reach her goal?