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It is late autumn and the students are starting to learn some tough lessons about what being a vet really means. In this episode they realise that not all cases have easy answers and get a taste of what it means to deliver bad news to owners.

Matt Wilkinson is working in the notoriously challenging neurology department. His first case is Blue, a large rhodesian ridgeback dog who is brought in by his distraught owner because he has had a series of seizures and cannot walk or respond. After a series of tests, Matt must help the dog's deeply upset owners to make the difficult decision of whether to put the dog through cancer treatment, which will give them some precious extra time with Blue.

Judy Puddifoot is on a farm placement pregnancy-testing cows. She helps head vet James McFarland to castrate a pet ram called Pierre.

Catherine Needham is at the RVC's Sainsbury's Beaumont practice in Camden, where she discovers how to worm a reluctant tortoise.

Charlie Tewson is on the highly challenging small animal medicine placement. He discovers just how complicated a case can be when he has to turn detective and solve the mystery of a jack russell with a serious autoimmune disease.

Dru Shearn learns important lessons about the competitive equine world. Dru's patient, Darcey Bustle, is a foal destined to be a dressage horse. But Darcey has a complicated problem with her shoulder and she will have to be put to sleep on the operating table if the equine surgery team cannot fix the problem.