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The doctor is called in to help 34-year-old Emma, who has been suffering from severe anxiety, panic attacks and depression since she was 19. She is refusing to see a counsellor and instead relies on a cocktail of antidepressants, alcohol, nicotine, caffeine and high-sugar foods. Dr Rangan must find a way to get to the bottom of Emma's mental health problems and break the vicious cycle that's destroying her life.

Despite James Murray's healthy lifestyle, he struggles with debilitating exhaustion and terrible sleep. For twenty years, his condition has been a mystery to doctors. Can Dr Rangan get to the root of his problem?