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In this next leg on the race to Ushuaia, Argentina, the most southerly city in the world, there are just four teams left to battle it out for the 拢20,000 prize. Setting off from Panama City, they take to the Caribbean Sea, bypassing the most dangerous place in the Western Hemisphere, the Darien Gap. Added complications ensue when a state of emergency is declared in Quito, Ecuador, the destination of their next checkpoint. The teams are forced to change their routes mid-race and head instead to Villavieja, in the remote Colombian desert.

Estranged uncle and nephew Emon and Jamiul start working better as a team the more they get to know each other. Not for the first time in the race, the pair miss a boat, but on this occasion they turn this to their advantage by earning much-needed cash at a scuba diving school. They also learn some vital route information that catapults them back into contention in the race.

Meanwhile, mother and son Jo and Sam find themselves in their own personal state of emergency as the pressure of the race ramps up. 19-year-old Sam is finding the long bus journeys a struggle, so Jo strikes a deal with him to take a break from the race and allows him to spend some of their budget to explore Medellin, home to drug kingpin Pablo Escobar, one of the world鈥檚 most notorious criminals. But an attempt by the pair to recoup some money working at a salsa bar in Cali has grave consequences, leaving their place in the race in jeopardy.