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In the autumn of 2019, cameras follow a new cast of characters from the London Ambulance Service as they care for the nine million people of the city.

Ambulance crew Kate and Femi are dispatched to a young man who is struggling to breathe. It turns out he鈥檚 suffering from severe anxiety, prompting Nigerian-born Femi to reflect on what he鈥檚 learned about the people here in the 18 years since he first came to the city.

Mandy, one of 24 dispatchers on duty today, sends crewmates Kayleigh and Lauren to help a young man in cardiac arrest. The case causes Mandy to reflect on what it is like to lose a son - something she has experienced herself.

By 10am, just three hours into the morning shift, control are dealing with the third assault of the day and have already responded to four stabbings. With the temperature gauge rising, control are taking over 300 emergency calls an hour.

The episode highlights the work of the London Ambulance Service as they tackle the consequences of knife crime in the capital and explores the devastating personal impact on those affected by the needless loss of young lives. These are the real human stories behind the sirens.