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In the final episode of the series, Dr Sam Willis is in Istanbul - the ancient city of Byzantium. Sam discovers how the eastern Roman Empire was ruled through silk and how Venetian merchants cashed in on the wealth and trade it generated.

Sam's last stop takes him full circle to Venice. Visiting Marco Polo's house, Sam reminds us how the great traveller's book was one of the first to link east to west and how the ideas and products that trickled down the Silk Road not only helped to trigger the Renaissance, but set Europe on a path of unstoppable change.