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Jo Cameron is a remarkable woman that's mystified doctors. She's 75, and feels almost no pain. She also finds herself unable to be sad or anxious for long.

Scientists at University College London had already worked out that it was because of a genetic mutation.

Now they've discovered how that mutation works at a molecular level, with potentially big ramifications for pain management, wound healing and mental well-being.

Andrei Okorokov is associate professor at UCL, and senior co-author of this study, published in the Neurology Journal, Brain. He, and Jo Cameron, speak to Newshour's Tim Franks.

(Photo: Jo Cameron is seventy-five years old, and feels almost no pain. Credit: Getty Images)