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Gary is in his forties and has a genetic condition causing his kidneys to fail. With a shortage of organ donors and a rapidly growing waiting list, he faces a lifetime of dialysis. His wife, Susan is desperate to help him by donating one of her kidneys, but their blood groups are not compatible, which makes direct donation impossible. They become part of an organ donation 鈥渃hain鈥� - a medical innovation linking up potential volunteer donors and their ill loved ones, across the UK. Their 鈥渃hain鈥� involves two other couples, but as the programme reveals, it鈥檚 not without its complications.